Binovision™ offers an innovative Amblyopia therapy, based on video games performing brain stimulation. The audiovisual stimulation encourages brain plasticity, typically bringing visual acuity improvement in a short time. Binovision™ amblyopia treatment was proven in a study, improving visual acuity improvement in just a few weeks.

Binovision™ introduces a revolutionary treatment modality for Amblyopia, based on real-time manipulation for streaming video content to perform audiovisual brain stimulation. Requiring just 1 hour a day of watching any streaming video content through a portable device, the stimulation encourages brain plasticity, typically bringing visual acuity improvement in a short time.

Binovision™’s amblyopia treatment utilizes dichoptic, dynamic binocular stimulation, using brightness/contrast oscillations and flickering, superimposed objects and audio cues. The amblyopic eye is stimulated by an image with increased intensity, while the fellow eye is stimulated by an image with decreased intensity.  The stimulation increases blood flow and perfusion, and strengthens synaptic connections in the brain to induce anti suppression of the Amblyopic eye.

Clinical Work

Study: Medisim performed an open label study comprising a single group of amblyopic children aged 4-8 years, with strabismus, anisometropia or both. Eligible children had best-corrected amblyopic eye visual acuity (BCVA) of 0.4–1.18 logMAR, and 0.18 logMAR or better in the fellow eye. All the children refused or were reluctant to use patching or atropine drops.

Goal: The study was designed to examine the efficacy and safety of Binovision™’s therapy.

Protocol: Each patient was instructed to watch TV shows & films, at home, using Binovision™™ for 30-60 minutes a day while using their best corrected visual acuity spectacles.

Study Head: Dr. Chaim Stolovitch MD, Chief of Pediatric Ophthalmology & Strabismus Unit at the Tel Aviv Medical Center & Dana Children’s Hospital, Israel.

Results:

The Mean VA in the amblyopic eye before treatment was 0.648 (±0.190).

At week 4 visit, mean VA improved significantly to 0.46 (0.183 ± 0.144 lines) in the amblyopic eye (P=0.0004).

As a control group, 8 patients completed 4 weeks of Sham (native images to both eyes, no stimuli protocol) and demonstrated no improvement from baseline VA in amblyopic eye.

At week 8 visit, mean VA improved to 0.394 (0.254 ± 0.1.69 lines) (P=0.000437) and at week 12 to 0.386 (0.26 ± 0.185 lines) (P=0.00098) from base line VA.

15 patients were re-examined 12 weeks after cessation of treatment, demonstrating change in mean VA of -0.12 line (P=0.575) suggesting the effect was sustained.

12 patients were re-examined 24 weeks after cessation, and demonstrated a very minor regression.

Type of amblyopia

Gender

Treatment history

Change in visual acuity of Amblyopic eye (logmar)

Response rate to treatment*

Conclusions

Binovision™ offers a potential alternative treatment to occlusion. Our amblyopia treatment’s content variety & familiarity contributed to the patients’ compliance.

Efficacy was observed in strabismic children and previously-treated children’s BCVA further improved.The effect was typically sustained after treatment completion, and no adverse effects were reported.

Amblyopia Researches

Amblyopia and binocular vision. By Eileen E. Birch. Progress in Retinal and Eye Research 33 (2013) 67-84

Using new findings, this article evaluates a new, binocular approach to amblyopia treatment in order to reduce or eliminate residual and recurrent amblyopia and improve the deficient ocular motor function and fine motor skills associated with amblyopia.

Amblyopia and the binocular approach to its therapy. Robert F. Hess a, Benjamin Thompson. Vision Research 114 (2015) 4–16

This article summarizes existing research on amblyopia, and interprets the therapeutic effects of binocular therapy and non-invasive brain stimulation in the context of various neural mechanisms.

Dichoptic training enables the adult amblyopic brain to learn. Jinrong Li, Benjamin Thompson, Daming Deng1, Lily Y.L. Chan, Minbin Yu, and Robert F. Hess. Current Biology Vol 23 No 8 R308

The article examines the effect of video stimulation on amblyopia and finds that this stimulation encourages brain plasticity, instigating a learning process that brings a positive impact on the patient’s condition.

New concepts concerning the neural mechanisms of amblyopia and their clinical implications. Agnes M.F. Wong, MD, PhD, FRCSC. CAN J OPHTHALMOL—VOL. 47, NO. 5, OCTOBER 2012

This article explores our current knowledge of the neural mechanisms that underly the symptoms associated with amblyopia. It also explores modern neuroimaging findings showing how amblyopia affects various brain regions. Finally, it reviews current concepts of brain plasticity and their implications for potential beneficial therapies.